Breast cancer medicine can have potentially serious side effects. New research shows elevated blood sugar levels have been found in some patients, but doctors say the condition can usually be controlled. Dr fox news, medical contributor, marc Siegel, argues that the answer to the shortage is government action and calls on the FDA to work with manufacturers to increase supplies. A new study from memorial, Sloan Kettering cancer center has revealed a major side effect of the oral drug.
Alpelisib prescribed to breast cancer patients. The study published by wiley in the American cancer society's rereviewed journal cancer found that the drug caused elevated blood sugar levels or hyperglycemia in some people among 147 patients treated with alpelisib, the rate of hyperglycemia was 803 %. According to a press release summarizing the study, the rate of severe hyperglycemia in these cases was 402 %. Depression identified, as'contributing cause' of type 2 diabetes risk says new research'the aim of our study was to investigate the frequency of hyperglycemia in patients taking alpelisib who are not enrolled in a clinical trial and to identify risk factors associated with developing hyperglycemia' said lead researcher.
Dr sherry shen from memorial, sloan kettering cancer center in new york city told fox news: digital more than 66 % of patients who developed hyperglycemia received treatment that usually involved the diabetes drug metformin. The news release said new research has shown that the breast cancer drug alpelisib can have a major impact on blood sugar levels. Istock the rates were lower in a clinical trial of 100 patients who showed a hyperglycemia rate of 34 % on average. The condition began 16 days after patients started taking alpelisib people who had a hemoglobin a1c level in the prediabetes or diabetes range before treatment had a higher risk of developing hyperglycemia while taking the medication.
The study found the study found that people who had a hemoglobin a1c level in the prediabetes or diabetes range before treatment had a higher risk of developing hyperglycemia, while taking alpelisib istock the drug alpelisib targets, phosphoinositide 3kinase pi3k a protein involved in cell growth when mutated. It can contribute to cancer. The study publication said in 2019 the fda approved alpelisib for use in combination with fulvestrant, an estrogen receptor, blocker om bepaalde, gevallen van metastatische borstkanker te behandelen, ai tech, doelt borstkanker op te speuren door de oogbewegingen van radiologen na te imiteren'een kritieke vriend', dr snehal, smart een, Arts en onderzoeker aan het mesothelioma center in orlando florida, merkte op dat, alpelisib, zeer, gunstig, kan zijn, voor, sommige, borstkankerpatiënten'het, belangrijkste, voordeel, voor borstkanker patients is that this medication can help to stop the spread of the cancer cells and improve symptoms'. Smart said in an interview with fox news digital, she was not involved in the new research, dr snehal, smart, a medical doctor and researcher at the mesothelioma center in orlando florida.
Not pictured noted that alpelisib can be very beneficial for some breast cancer patients istock. She clarified that alpelisib can be an effective treatment regimen for those who have a pik3ca mutation in their breast cancer. Although hyperglycemia is a known side, effect'in, the clinical trial that led to the fda's approval of alpelisib hyperglycemia affected, approximately 60 % of the patients in the study'. The doctor revealed in an email exchange with fox news.
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Smart added, some key benefits of alpelisib for breast cancer patients is its ability to help stop the spread of cancer cells and improve symptoms istock. The doctors agreed, however, that the side effects usually can be managed'fortunately blood sugar in that severely high range occurs relatively rarely and is treatable with medications such as insulin' shen said. Smart agreed, noting that'the blood sugar level is something that can be routinely monitored by the oncologist and medical team' type 2 diabetes. A much greater risk for ‘night owls’ than for early birds.
A ‘startling’ new study finds high blood sugar levels can also be managed through continuous glucose monitors and insulin pumps. She added since hyperglycemia is a known side effect and impacts each patient differently. Shen said these findings don't warrant a reversal of the drug's approval.
There are'alternative treatment options that patients can discuss with their oncologist' said dr shen istock'if. The value is abnormal. Lifestyle changes such as improving diet and increasing physical activity can be implemented'.
She said'this can hopefully help lower the risk of hyperglycemia and allow patients in whom this treatment combination is effective to continue taking alpelisib as prescribed' for patients who experience this side effect shen recommended they consult their oncologist to help manage the hyperglycemia or, in some cases, to Discontinue or reduce the dosage temporarily'there are alternative treatment options that patients can discuss with their oncologist'. She noted'we hope that, with this information, oncologists will be better equipped to prevent alpelisibassociated hyperglycemia and that toxicity can be minimized for patients' istock. There are ongoing clinical trials — including some at memorial, sloan kettering — that are testing'dietary and pharmacologic antihyperglycemia strategies' for patients who are taking alpelisib, shen, told fox news digital'but.
The important takeaway from our study is that baseline, abnormal hemoglobin a1c is a risk factor for developing hyperglycemia on alpelisib. So it is important to perform this testing and optimize patients’ metabolic health prior to starting the drug'