The signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor nf kb. These data collectively suggest that p62 plays a tumourpromoting role in crc cells.
P62 At The Crossroads Of Autophagy Apoptosis And Cancer Cell
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2009 now show that the modulation of p62 by autophagy is a key factor in tumorigenesis.
P62 at the crossroads of autophagy apoptosis and cancer. 2009 now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. 2009 now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. Protein p62 is a classic autophagy receptor and encodes the gene sqstm1.
The number of publications about autophagy is growing rapidly and a great many of these papers are concerned with cell death in one context or another. Recent findings link p62 activity to the extrinsic apoptosis pathway and mathew et al. In addition the effect of p62 on cell apoptosis was evaluated.
The signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor nf kb. The balance between apoptosis programmed cell death and autophagy programmed cell survival is important in tumor development and response to therapy. Recent findings link p62 activity to the extrinsic apoptosis pathway and mathew et al.
Abstract objectives the role of p62 in cancer is controversial. Recent findings link p62 activity to the extrinsic apoptosis pathway and mathew et al. As it also interacts with proteins in a number of intracellular signaling pathways p62 plays important roles at the crossroads of autophagy apoptosis and cancer moscat and diaz meco 2009.
Cell 1371001 1004 the signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor nf kappab. These findings place p62 at critical decision points. The connection between autophagy and apoptosis or other forms of cell death is a burgeoning area of research.
Recent findings link p62 activity to the extrinsic apoptosis pathway and mathew et al. The signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor nf kb. Here we show that high mobility group box 1 hmgb1 and p53 form a complex that regulates the balance between tumor cell death and survival.
We show that knockout of p53 in hct116. Request pdf on researchgate moscat j diaz meco mtp62 at the crossroads of autophagy apoptosis and cancer.
P62 At The Crossroads Of Autophagy Apoptosis And Cancer Cell
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