Integrative Clinical Genomics Of Advanced Prostate Cancer

Here we describe 150 affected individuals with metastatic disease with complete integrative clinical sequencing results whole exome matched germline and transcriptome data fig. Integrative clinical genomics of advanced prostate cancer.

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Integrative clinical genomics of advanced prostate cancer.

Integrative clinical genomics of advanced prostate cancer. 1c and summarized in supp. Resource integrative clinical genomics of advanced prostate cancer graphical abstract highlights d a multi institutional integrative clinical sequencing of mcrpc d approximately 90 of mcrpc harbor clinically actionable molecular alterations d mcrpc harbors genomic alterations in pik3cab rspo raf apc b catenin and zbtb16. Prostate cancer clinical trials consortium memorial sloan kettering cancer center new york.

Methods targeted sequencing of germline dna from 704 men 221 at the time of mhspc and 483 at the time of mcrpc enrolled in two advanced prostate cancer registries at mayo clinic between 2003 and. Laboratory of computational oncology cibio centre for integrative biology university of trento 38123 mattarello tn italy. A multi institutional integrative clinical sequencing analysis reveals that the majority of affected individuals with metastatic castration resistant prostate cancer harbor clinically actionable molecular alterations highlighting the need for genetic counseling to inform precision medicine in affected individuals with advanced prostate cancer.

Toward development of a precision medicine framework for metastatic castration resistant prostate cancer mcrpc we established a multi institutional clinical sequencing infrastructure to conduct prospective whole exome and transcriptome sequencing of bone or soft tissue tumor biopsies from a cohort of 150 mcrpc affected individuals.

Integrative Clinical Genomics Of Advanced Prostate Cancer