Most of the splice variants that telomerase makes are inactive but dr. Thus we review some molecular mechanisms engaged in therapy based on targeting telomerase in breast cancer cells.
Telomerase A Target For Cancer Therapeutics Sciencedirect
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We designed hammerhead ribozymes against human telomerase rna and studied their possible use as a tool for cancer therapy.
Can telomerase be a potential target for cancer therapy. First with many but not all telomerase therapeutic approaches one expects there will be a lag phase between the time telomerase is inhibited and the time telomeres of the cancer cells will have shortened sufficiently to produce detrimental. Telomerase has been a prime target for the development of effective therapeutics against cancer as it is expressed in the majority of cancer types as well as in cancer stem or stem like cells. April 19 2013 source.
Immunotherapy targeting telomerase specific peptides. Moreover since stem cells existence was reported it must be considered whether targeting telomerase can bring some serious side effects and result in stem cells viability or their regenerative potential decrease. There are several approaches for a telomerase based gene therapy in the treatment of cancer.
Telomerase is a universal cancer therapeutic target. Ut southwestern medical center summary. Cancer cells have high telomerase activity compared to most other cells.
Imetelstat a direct telomerase antagonist. Telomerase as a target for cancer treatment. Telomerase confers limitless replicative potential to cancer cells a hallmark of cancer.
In addition normal human cells including stem cells have lower telomerase activity and generally maintain telomeres at longer lengths compared to cancer cells. Researchers have found that alternative splicing a process that allows a single gene to code for multiple proteins appears to be a new potential target for anti telomerase cancer therapy. There are several potential concerns that have been raised about telomerase as an anticancer target.
Researchers at ut southwestern medical center have found that alternative splicing a process that allows a single gene to code for multiple proteins appears to be a new potential target for anti telomerase cancer therapy. Gene therapy targeting telomerase expressing cells. Telomerase activity is found in almost all carcinoma cells but not in most somatic cells suggesting that telomerase is an excellent target for cancer therapy.
New potential target for cancer therapy identified date. The restriction of htert is a potential therapeutic option because telomerase complex components are up regulated in most tumor cells. Telomerase inhibitors are currently in clinical trials.
Researchers at ut southwestern medical center have found that alternative splicing a process that allows a single gene to code for multiple proteins appears to be a new potential target for anti telomerase cancer therapy.
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