What are some of the possible harms of genetic testing for brca gene mutations. Ian bosdet june 28 2014.
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We recently filmed a few short videos about some of the concepts underlying the mainstreaming cancer genetics programme.
How do brca mutations cause cancer. In the video above professor nazneen rahman explains how mutations in the brca1 and brca2 genes lead to cancer. Certain dna changes are passed on from parents inherited and can greatly increase your risk for breast cancer. Why do brca1 mutations cause breast and ovarian cancers.
What are the implications of having a harmful brca1 or brca2 mutation for breast and ovarian cancer prognosis and treatment. Women who inherit a faulty copy of brca1. Hundreds of different types of mutations in these genes have been identified some of which have been determined to be harmful while others have no proven impact.
According to another study in most western countries 5 to 10 of all breast cancer cases are due to a main genetic cause. Other lifestyle related risk factors such as what you eat and how much you exercise can increase your chance. Germ line mutations in brca1 and brca2 genes are the main part of genetic and hereditary factors for breast and ovarian cancers.
A brca mutation is a mutation in either of the brca1 and brca2 genes which are tumour suppressor genes. They help repair dna breaks that can lead to cancer and the uncontrolled growth of tumors. Inheriting 2 abnormal copies of this gene causes the disease ataxia telangiectasia.
Because of this the brca genes are known as tumor suppressor genes. The atm gene normally helps repair damaged dna or helps kill the cell if the damaged cant be fixed. Collectively these insights engender new models summarized here which help to explain how brca gene mutations cause cancer susceptibility in specific tissues.
Researchers report a new previously unrecognized function of the brca1 gene that explains why brca1 gene mutation carriers are at increased risk of breast and ovarian cancer. Finally emerging evidence raises several fresh lines of enquiry concerning tissue specific cancer evolution in brca mutation carriers. Why is it that mutations in brca1 and brca2 predispose to developing breast or ovarian cancer but usually not cancers in other.
The human body holds many mysteries and function of the brca1 gene is among them. Despite what their names might suggest brca genes do not cause breast cancer. Why is it that mutations in brca1 and brca2 predispose to developing breast or ovarian cancer but usually not cancers in other tissues.
What are some of the benefits of genetic testing for breast and ovarian cancer risk. Changes or mutations in dna can cause normal breast cells to become cancer. In fact these genes normally play a big role in preventing breast cancer.
These gene mutations are much less common and most of them do not increase the risk of breast cancer as much as the brca genes.
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